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DESCRIPTION
This drug inhibits the activity of a certain enzyme in the central nervous system, which slows abnormal and excessive discharge from central nervous system neurons.
This action also results in a decreased pressure.
ORIGINAL USES (ON-LABEL)
Glaucoma (chronic simple open-angle, secondary glaucoma, preoperatively in acute angle-closure), drug-induced edema (swelling related to fluid retention) or edema due to congestive heart failure, some types of seizures (immediate release dosage form), prevention or amelioration of symptoms associated with acute mountain sickness.
NEWLY DISCOVERED USES (OFF-LABEL)
Meniere's Disease
POTENTIAL SIDE EFFECTS
Flushing, incoordination of muscles, confusion, depression, allergic skin reaction, photosensitivity (skin reaction related to sun exposure), electrolyte imbalance, increased blood or urine glucose, appetite decreased, diarrhea, nausea, frequent urination, blood disorders, liver disorders, numbness, hearing disturbance, ringing in the ears.
CAUTIONS
- Notify your doctor if you have an allergy to sulfonamides (antibacterials or diuretics) prior to therapy with this drug, as this drug should not be taken in patients with sulfonamide allergies.
- Not for use in liver disease or insufficiency (may result in coma), with decreased sodium and or potassium levels, adrenal gland insufficiency, severe kidney disease or dysfunction, severe lung obstruction.
- Not for long-term use if you have noncongestive angle-closure glaucoma.
- Requires blood monitoring during therapy to screen for blood disorders.
- Use with caution if you are diabetic.
- Impaired mental alertness and/or physical coordination may occur.
DRUG INTERACTIONS
Diflunisal, cyclosporine, salicylates, lithium, amphetamines, quinidine,
primidone
FOOD INTERACTIONS
Unknown
HERBAL INTERACTIONS
Unknown
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk; breast-feeding not recommended during therapy.
SPECIAL INFORMATION
If you experience stomach upset when using this drug, take with food. Capsules may be opened and sprinkled over soft food. Avoid prolonged exposure to sunlight, and wear sunscreen during therapy. This drug may cause drowsiness, so use caution while performing tasks that require alertness. Notify your doctor if you develop a sore throat, fever, unusual bruising or tingling in the hands and feet during therapy.
Acetazolamide has been studied in cats, and had been noted to decrease lymph pressures of the inner ear.
In one analysis in The American Journal of Otology, people with Meniere's disease were given this drug or chlorthalidone and the short-term and long-term effects on the rate of hearing loss were evaluated.
Treatment with acetazolamide or chlorthalidone was useful in the testing of hearing function and in managing of vertigo attacks.
However, these treatments were not useful in the long-term prevention of hearing loss that occurs with Meniere's disease.
In an earlier study, the immediate effects of acetazolamide were evaluated in 30 patients with Meniere's disease, where it caused fluid shifts in the inner ear.
In another study from the University of Budapest, 60 patients suffering from Meniere's disease for more than eight years were treated with Diamox in varying doses.
This study evaluated the drug's effects on hearing function and symptoms of tinnitus.
Researchers observed successful response to therapy in newly diagnosed patients and those younger than age 50.
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