DESCRIPTIONCarbamazepine belongs to a class of drugs known as mood stabilizers. Depending on its use, this drug also may be classified as an antineuralgic, antimanic, antipsychotic, antidiuretic, or anticonvulsant drug. It is used to control some types of seizures in the treatment of epilepsy; also it may be used to relieve neurogenic pain, to prevent bipolar disorder symptoms, and to treat a certain type of diabetes, alcohol withdrawal, or some mental illnesses.
ORIGINAL USES (ON-LABEL)
Certain types of seizures (partial seizures, generalized tonic-clonic, mixed seizure patterns, or other partial or generalized seizures), trigeminal neuralgia.
NEWLY DISCOVERED USES (OFF-LABEL)
Alcohol withdrawal psychosis, Alzheimer's disease, benzodiazepine withdrawal, central neurogenic diabetes insipidus, chronic neuropathic pain, cocaine addiction, diabetes insipidus, diabetic neuropathy, hiccups, migraine prevention in children, multiple sclerosis, partial central diabetes insipidus, postpartum psychosis and lactation, post-traumatic stress disorder (PTSD), schizoaffective disorder, vulvodynia.
POTENTIAL SIDE EFFECTS
Edema, congestive heart failure, fainting, slow heart rate, sedation, dizziness, fatigue, uncoordinated gait, rash, hives, severe skin reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome), decreased sodium levels, fever, chills, nausea, vomiting, gastric distress, abdominal pain, urinary retention, kidney dysfunction, impotence, blood disorders (e.g., aplastic anemia, agranulocytosis, eosinophilia, leukopenia), changes in liver function, jaundice, liver failure, blurred vision, uncontrolled eye movements, lens opacities, eye irritation and inflammation, ringing in the ears.
CAUTIONS
- Not for use if you have marrow suppression or certain blood disorders. Potentially fatal blood cell abnormalities have been reported with the use of this drug.
- Do not use while taking MAO inhibitors; these drugs should be discontinued for a minimum of 14 days before carbamazepine is begun.
- Notify your doctor if you have a history of heart damage or liver disease.
- Severe skin reactions have been reported rarely, but may be serious. Report any sign of rash to your doctor immediately.
- Requires baseline assessment of blood, liver and kidney function, and eye exam.
- Elderly may have increased risk of SIADH-like (syndrome of inappropriate diuretic hormone).
Protease inhibitors, cimetidine, clarithromycin, danazol, diltiazem, erythromycin, felbamate, fluoxetine, fluvoxamine, isoniazid, lamotrigine, metronidazole, propoxyphene, verapamil, fluconazole, itraconazole, ketoconazole, acetaminophen, lithium, benzodiazepines, citalopram, clozapine, corticosteroids, cyclosporine, doxycycline, ethosuximide, felbamate, felodipine, haloperidol, mebendazole, methadone, oral contraceptives, phenytoin, tacrolimus, theophylline, thyroid hormones, tricyclic antidepressants, valproic acid, warfarin, mefloquine.
FOOD INTERACTIONS
Alcohol. Avoid concurrent use with grapefruit juice. Take with food.
HERBAL INTERACTIONS
Evening primrose, valerian, St. John's wort, kava kava, gotu kola, quinine.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category D. This drug is excreted in breast milk. Consult your doctor prior to beginning breast-feeding.
SPECIAL INFORMATION
This drug has a black box warning regarding the potential for serious blood disorders. Requires assessment of blood prior to the initiation of therapy and periodic monitoring thereafter.
Researchers in Germany evaluated the efficacy of carbamazepine for benzodiazepine withdrawal. In 18 patients, a benzodiazepine drug was withdrawn. The dose was gradually reduced in nine patients; the other nine patients were given carbamazepine syrup for 15 days after the benzodiazepine drug was stopped. In those patients treated with carbamazepine, there was a trend toward less severe benzodiazepine withdrawal symptoms. Researchers concluded that carbamazepine offers a therapeutic benefit for those at risk for benzodiazepine withdrawal.
In another study, researchers in Poland found that this drug was found to be comparable with another drug used for benzodiazepine withdrawal, tianeptine, and was safe and effective in treating withdrawal symptoms. These two studies provide some evidence that Tegretol may be helpful for benzodiazepine withdrawal but more evidence is needed.
Buy Tegretol online
Where can I buy Tegretol without prescription?Carbamazepine is a prescription drug that comes in 100 mg, 200 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Carbamazepine without prescription. You may be able to order Tegretol from them online and save the local pharmacy markup.
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What is Carbamazepine?
This drug is used to control seizures and to treat certain pain syndromes.
This drug is used to control seizures and to treat certain pain syndromes.
BRAND NAME
Atretol, Carbatrol, Epitol, Tegretol
GENERIC NAME
Carbamazepine
CHEMICAL CLASS
Iminostilbene derivative
THERAPEUTIC CLASS
Anticonvulsant; antimanic; antineuralgic; antipsychotic
Atretol, Carbatrol, Epitol, Tegretol
GENERIC NAME
Carbamazepine
CHEMICAL CLASS
Iminostilbene derivative
THERAPEUTIC CLASS
Anticonvulsant; antimanic; antineuralgic; antipsychotic
AVAIL FORMS
Tablets — Oral 100 mg, 200 mg.
Tablets — Oral 100 mg, 200 mg.
DOSAGE
Adult
Seizures: PO 200 mg bid; may be increased by 200 mg/day in divided doses q6-8h; maintenance 800-1200 mg/day; max 1200 mg/day.
Trigeminal neuralgia: PO 100 mg bid; may increase 100 mg q12h until pain subsides; not to exceed 1.2 g/day; maintenance is 200-400 mg bid.
Antidiuretic: PO 300-600 mg/day, as sole therapy; 200-400 mg/day, if concurrent with other antidiuretic agents.
Antipsychotic: PO 200-400 mg/day divided tid-qid; max 1600 mg/day.
Child <12 yr
Seizures: PO 10-20 mg/kg/day in 2-3 divided doses
Adult
Seizures: PO 200 mg bid; may be increased by 200 mg/day in divided doses q6-8h; maintenance 800-1200 mg/day; max 1200 mg/day.
Trigeminal neuralgia: PO 100 mg bid; may increase 100 mg q12h until pain subsides; not to exceed 1.2 g/day; maintenance is 200-400 mg bid.
Antidiuretic: PO 300-600 mg/day, as sole therapy; 200-400 mg/day, if concurrent with other antidiuretic agents.
Antipsychotic: PO 200-400 mg/day divided tid-qid; max 1600 mg/day.
Child <12 yr
Seizures: PO 10-20 mg/kg/day in 2-3 divided doses
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