Celebrex (celecoxib) is used to relieve the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA) in adults.
In the body, there are 2 enzymes that are called COX-1 and COX-2. COX-1 helps regulate normal cell function in the stomach and blood. COX-2 plays a role in causing arthritis pain and inflammation. Celebrex is the first arthritis product to target only the COX-2 enzyme.
Celebrex capsules come in two strengths: 100 mg and 200 mg. The recommended dose for OA is 200 mg a day, which may be taken as a single 200 mg dose or as a 100 mg dose twice a day. The recommended dose for RA is 100 mg to 200 mg, twice a day. Talk to your doctor or healthcare professional to find out how you should take Celecoxib. You should continue to take Celebrex as prescribed even when you are feeling better. This drug can be taken with or without food.
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You should not take Celebrex if you:
Celebrex can cause fluid retention and swelling in some patients. Check with your health care provider to see if Celebrex is right for you, if you:
Tell your health care provider if you are trying to become pregnant, are already pregnant, or are breast-feeding. Because certain medications may interact with NSAIDs or Celebrex, review all medications that you take with your health care provider, including those that you take without a prescription. Your health care provider may have to adjust your dose or monitor you more closely if you take:
Side effects can include:
Serious problems such as stomach ulcers and bleeding are recognized complications in people treated with NSAIDs. Similar problems have occurred in people treated with Celebrex, although very rarely. The likelihood of stomach problems increases the longer you take drugs like Celebrex. However, even short-term treatment is not without risk. These problems can happen without any warning, but in some people may cause symptoms such as gnawing or burning stomach pain, black or tarry stools, or vomiting. If this happens, stop taking it and call your health care provider right away.
Although serious problems such as liver damage have occurred in people treated with NSAIDs, there have been no similar problems to date in patients treated with this drug. Some of the warning signs of liver damage can be nausea, vomiting, fatigue, loss of appetite, yellow coloring of skin or eyes, and dark urine. If this happens call your health care provider right away.
NOTE: While low-dose aspirin to prevent heart attack or stroke can be used with it, people who take aspirin and Celecoxib together are at increased risk of developing stomach ulcers compared with those taking Celebrex alone. It is not a substitute for aspirin for prevention of heart attack or stroke.