DESCRIPTION
Gabapentin belongs to a class of drugs known as anticonvulsants, used to help control seizures in the treatment of epilepsy. It is also used to control pain associated with shingles and has been evaluated for pain conditions, including migraine, as its pain-modulating properties may regulate the perception of pain. Anticonvulsant drugs, such as gabapentin, are becoming increasingly popular for migraine prevention.
ORIGINAL USES (ON-LABEL)
Post-herpetic neuralgia, epilepsy.
NEWLY DISCOVERED USES (OFF-LABEL)
Alcohol withdrawal, attention deficit hyperactivity disorder (ADHD), chronic neuropathic pain, cocaine addiction, diabetic peripheral neuropathy, generalized anxiety disorder (GAD), fibromyalgia, menopause, migraine prevention, panic disorder, post-traumatic stress disorder (PTSD), social phobia, trigeminal neuralgia.
POTENTIAL SIDE EFFECTS
Drowsiness, dizziness, muscle incoordination, fatigue, fever, emotional lability, nausea, upset stomach, dry mouth, double vision, blurred vision.
CAUTIONS
- Avoid abrupt discontinuation of therapy.
- Use with caution if you have renal impairment, or if you are elderly.
- Use with caution when operating heavy machinery or driving.
- Monitor for possible mood disturbances or psychological changes when using this drug in children.
DRUG INTERACTIONS
Cimetidine may increase the levels of gabapentin. Gabapentin may increase the levels of
norethindrone if given concurrently. Caution use with other drugs that may cause sedation (such as sedatives, alcohol).
FOOD INTERACTIONS
Alcohol
HERBAL INTERACTIONS
Evening primrose, valerian, St. John's wort, kava kava, and gotu kola.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excretion in breast milk unknown. Nursing is not recommended.
SPECIAL INFORMATION
International and domestic studies that have evaluated Neurontin for migraine prevention suggest that it is effective. In a study of 63 patients with migraine (with or without aura), gabapentin significantly reduced migraine frequency and intensity among 30 patients who received it. In this study, adverse events were mild to moderate in severity.
Similarly, in a large study, 143 people with migraine received daily doses of gabapentin or placebo for 12 weeks. At the end of 12 weeks, the migraine rate had declined from 4.2 migraines before treatment to 2.7 migraines after treatment in those who received gabapentin. This decrease was significantly greater than the decrease from 4.1 migraines to 3.5 migraines among those who received placebo. Of the 56 gabapentin recipients, 46% had at least a 50% reduction in the four-week migraine rate. Drug-related adverse events (sleepiness and dizziness) led to drug withdrawal in 13% of patients in the gabapentin group compared with 7% in the placebo group. The researchers concluded that Neurontin is an effective and well-tolerated preventive for migraine.
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Gabapentin is a prescription drug that comes in 300 mg, 400 mg capsules.
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