DESCRIPTION
Sertraline belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) and is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), post-traumatic stress disorder (PSTD), and social anxiety disorder. It is thought to work by increasing the activity of a chemical in the brain known as serotonin; this SSRI-type antidepressant has been shown to be effective and well tolerated if you are affected with seasonal affective disorder.
ORIGINAL USES (ON-LABEL)
Treatment of major depression, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, social anxiety disorder.
NEWLY DISCOVERED USES (OFF-LABEL)
Attention deficit hyperactivity (ADHD), alcoholism (cravings and dependence), Alzheimer’s disease, bulimia, childhood anxiety, chronic fatigue syndrome, nocturnal enuresis, premature ejaculation, seasonal affective disorder.
POTENTIAL SIDE EFFECTS
Insomnia, solomnence, dizziness, headache, fatigue, dry mouth, diarrhea, nausea, ejaculatory disturbances, palpitations, agitation, anxiety, nervousness, rash, decreased libido, constipation, anorexia, upset stomach, flatulence, urinary disorders, tremors, numbness, visual difficulty, abnormal vision, increased sweating, ringing in the ears, changes in weight, low sodium levels, decrease in uric acid levels.
CAUTIONS
- Notify your doctor if you have a latex allergy as the dropper of the concentrated solution formulation contains dry natural rubber.
- Use may be associated with the development of suicidal ideation and behavior (see special information section).
- Do not use if you have been taking an MAO inhibitor (e.g., phenelzine, tranylcypromine, isocarboxazid) with in the past 14 days. Wait 5 weeks after stopping sertraline before starting a nonselective MAO inhibitor and 2 weeks before starting sertraline after stopping a MAO inhibitor. When used with MAO-Is fever, high blood pressure, increased heart rate, confusion, seizures, and deaths have been reported.
- Gradually decrease in dosage upon discontinuation of therapy.
- Notify your doctor if you have a history of mania, seizures, alcoholism.
- Use caution with liver dysfunction, or kidney insufficiency, or in elderly patients.
- Concurrent use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of bleeding.
DRUG INTERACTIONS
MAO inhibitors (such as phenelzine, isocarboxazid, or linezolid), selegiline, warfarin, cimetidine, linezolid, metoclopramide,
sibutramine,
tramadol, phenytoin, l-tryptophan, tricyclic antidepressants (such as
amitriptyline,
nortriptyline,
imipramine, etc.), benzodiazepines (such as
diazepam, flurazepam, temazepam, etc.), carbamazepine, clozapine, lithium, NSAIDs, pimozide, tolbutamide, glimepiride, sumatriptan,
zolpidem.
FOOD INTERACTIONS
May be given with or without food. Avoid alcohol.
HERBAL INTERACTIONS
Valerian, St. John's wort, SAMe, kava kava.
PREGNANCY AND BREAST-FEEDING CAUTIONS
Pregnancy category C; excretion into breast milk unknown, use caution in nursing mother.
SPECIAL INFORMATION
ADHD and major depression are common ailments throughout life, and these two disorders may occur at the same time. In a study conducted at Case Western Reserve University, seven children with ADHD and major depression were examined.
For all 11 patients, symptoms of major depression appeared to respond well to either Prozac or Zoloft.
Using fluoxetine or this drug daily, there was no adverse behavioral effects.
However, no improvement in ADHD symptoms was observed in any patient during the administration of
Prozac or Zoloft when used alone.
Combination treatment with a psychostimulant seemed necessary for chronic ADHD symptoms to be effectively addressed.
No patient developed suicide impulses, increased aggressiveness, mania, or other problematic side effects.
Researchers concluded that this combination therapy was well tolerated and appeared to be effective in treating both ADHD and depressive symptoms.
According to the study, the results suggest that add-on treatment with psychostimulants might be a safe and effective intervention for children treated with fluoxetine or sertraline who have persistent ADHD symptoms.
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Sertraline antidepressant is a prescription drug that comes in 50 mg, 100 mg tablets.
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